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In conjunction with no obvious histopathological toxicity signs, decorin represents a promising substance to inhibit PVR reactions. In conclusion, in this rabbit model of PVR, adjuvant decorin application during vitrectomy effectively reduces fibrosis and TRD development. There were no drug-related toxic effects evident on clinical and histopathological examination.

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In decorin-treated eyes, vitrectomy outcome was best when preformed at 1 week after trauma. Data related to grain size, microstratigraphy, and basic morphology were obtained through the optical software programs JMicrovision and ImageJ 37,38. TRD was prevented in 13 rabbits out of 15 in GIII to 14 rabbits out of 15 in GIV. Depending on dosage and time of vitrectomy, PVR could be completely avoided (PVR score = 0) in 16 rabbits out of 30. The best results were obtained when surgery was used in conjunction with decorin that reduced both the PVR score and fibrosis development significantly (p < 0.05). Vitrectomy had a positive effect (p < 0.05) on PVR development when preformed immediately, however the developed fibrosis was high. The control group GI developed severe PVR with tractional retinal detachment (TRD) (PVR score ≥2) in four rabbits out of five. The amount of fibrosis was quantified using JMicroVision© software. GIII and GIV received 100 μg or 200 μg decorin, respectively.

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Groups (GII-GIV) consisted of subgroups receiving phacovitrectomy at three different time points (a) at the time of trauma, (b) 1 week following trauma, and (c) 2 weeks following trauma. Imagej Tutorial : How to Set scale bar in micro-structure using imagej Mirtunjay Kumar 1. One group (GI) reveals a control with no treatment after trauma. Traumatic PVR was induced in 50 rabbits divided into ten groups (n = 5). This study evaluates the effect of decorin, a naturally occurring TGF-ß inhibitor, in an experimental rabbit model for proliferative vitreoretinopathy (PVR). It is therefore prohibited the use of these for profit and / or without my permission.The cytokine transforming growth factor-ß (TGF-ß) is a pivotal contributor to tissue fibrosis and a key cytokine in the pathogenesis of cellular transdifferentiation, epithelial-mesenchymal transition (EMT), and cell adhesion. The photos on this site are my sole property. The photos on this website were taken with a Canon EOS 60D digital camera mounted on a Zeiss Axioplan microscope owned by the Department of Earth Sciences, University of Pisa. Each page consists of two parts, descriptive (an exhaustive explanation of the mineral phase) and visual (high-resolution photographs) the information contained on the pages are taken from various university textbooks and scientific papers, cited throughout the text. The website is designed for students of geology, petrography and geology enthusiasts, and for those who are interested in this matter. The passion for the optical petrography inspired me to create this website with the aim to provide a tool that would ease the recognition and identification of mineral phases in thin section. In 2018 I obtained a PhD at 'A.Desio' Earth Science Department in Milan (Italy).

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The actual developer of the free software is JMicroVision. JMicroVision is compatible with Windows XP/Vista/7/8/10/11 environment, 32-bit version.

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We cannot confirm if there is a free download of this software available. Follow name is Alessandro Da Mommio, I graduated in 2009 in Earth Sciences (first level degree) at the University of Pisa, and I obtained the MSc in Earth Sciences and Technologies at the same University in 2013. There was a download of JMicroVision 1.2.7 on the developer's website when we last checked.

Jmicrovision software